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                产品编号 bs-55207R
                英文名称 SQSTM1/p62
                中文名称 泛素结合蛋白P62抗体
                别    名 A170; EBI 3 associated protein of 60 kDa; EBI3 associated protein of 60 kDa; EBI3-associated protein of 60 kDa; EBIAP; MGC127197; ORCA; OSF-6; Osi; OSIL; Oxidative stress induced like; p60; p62; p62B; Paget disease of bone 3; PDB 3; PDB3; Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa; Phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; PKC-zeta-interacting protein; Protein kinase C-zeta-interacting protein; Sequestosome 1; Sequestosome-1; SQSTM 1; SQSTM_HUMAN; Sqstm1; STAP; STONE14; Ubiquitin binding protein p62; Ubiquitin-binding protein p62; ZIP 3; ZIP; ZIP3  
                研究领域 心血管  染色质和核信号  信号转导  细胞凋亡  转录调节因子  表观遗传学  
                抗体来源 Rabbit
                克隆类型 Polyclonal
                交叉反应 Human, Mouse, Rat, 
                产品应用 WB=1:500-2000 IHC-P=1:50-100 (石蜡切片需做抗原修复)
                not yet tested in other applications.
                optimal dilutions/concentrations should be determined by the end user.
                分 子 量 38/47kDa
                细胞定位 细胞核 细胞浆 
                性    状 Liquid
                浓    度 1mg/ml
                免 疫 原 Recombinant human SQSTM1/p62:1-440 
                亚    型 IgG
                纯化方法 affinity purified by Protein A
                储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
                保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
                PubMed PubMed
                产品介绍 Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

                Function:
                Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

                Subunit:
                Cytoplasm. Late endosome. Nucleus. Endoplasmic reticulum. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum.

                Subcellular Location:
                Cytoplasm. Late endosome. Nucleus. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.

                Tissue Specificity:
                Ubiquitously expressed.

                Post-translational modifications:
                Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN.

                DISEASE:
                Defects in SQSTM1 are a cause of Paget disease of bone (PDB) [MIM:602080]. PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma. PDB is a chronic disease affecting 2 to 3% of the population above the age of 40 years.

                Similarity:
                Contains 1 OPR domain.
                Contains 1 UBA domain.
                Contains 1 ZZ-type zinc finger.

                SWISS:
                Q13501

                Gene ID:
                8878

                Database links:

                Entrez Gene: 8878 Human

                Entrez Gene: 18412 Mouse

                Entrez Gene: 113894 Rat

                Omim: 601530 Human

                SwissProt: Q13501 Human

                SwissProt: Q64337 Mouse

                SwissProt: O08623 Rat

                Unigene: 709030 Human

                Unigene: 40828 Mouse

                Unigene: 107103 Rat



                Important Note:
                This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

                产品图片
                Sample:
                Lane 1: 293T (Human) Cell Lysate at 25 ug
                Lane 2: SQSTM1 / p62 knockout (KO) 293T (Human) Cell Lysate at 25 ug
                Primary: Anti-SQSTM1 / p62 (bs-55207R) at 1/1000 dilution
                Secondary: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution
                Predicted band size: 62 kD
                Observed band size: 62 kD
                Sample:
                Lane 1: Liver (Mouse) Lysate at 40 ug
                Lane 2: Stomach (Mouse) Lysate at 40 ug
                Lane 3: Kidney (Mouse) Lysate at 40 ug
                Lane 4: Spleen (Mouse) Lysate at 40 ug
                Lane 5: Muscle (Mouse) Lysate at 40 ug
                Lane 6: Small intestine (Rat) Lysate at 40 ug
                Lane 7: Hela (Human) Cell Lysate at 30 ug
                Lane 8: A549 (Human) Cell Lysate at 30 ug
                Lane 9: Panc-1 (Human) Cell Lysate at 30 ug
                Primary: Anti-SQSTM1/p62 (bs-55207R) at 1/1000 dilution
                Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
                Predicted band size: 62 kD
                Observed band size: 60 kD
                Paraformaldehyde-fixed, paraffin embedded (Mouse liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SQSTM1) Polyclonal Antibody, Unconjugated (bs-55207R) at 1:100 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
                Paraformaldehyde-fixed, paraffin embedded (Human appendix); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SQSTM1) Polyclonal Antibody, Unconjugated (bs-55207R) at 1:100 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
                Paraformaldehyde-fixed, paraffin embedded (Rat ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SQSTM1) Polyclonal Antibody, Unconjugated (bs-55207R) at 1:100 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
                U2-OS cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (KO Validated)SQSTM1/p62 polyclonal Antibody, Unconjugated (bs-55207R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.
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